If you notice any other effects, check with your healthcare professional. This drug is registered worldwide as a veterinary antiparasitic agent for use in companion and farm animals. There are no known significant interactions. The following is a list of possible side-effects that may occur in medicines that contain Moxidectin. These are not all of the side effects that may occur. So it appears, with a real minimum of information, that a human effective dose would be between 0.15 and 0.6 mg per kg or approximately 0.1 to 0.3 mg per pound. There are no contraindications listed in the manufacturer’s labeling. Treatment of severe Mazzoti reactions is not definitive, but includes supportive care (eg, hydration and/or parenteral corticosteroids) to treat postural hypotension. (And, in case you missed it … there’s 3 times as much moxidectin in ProHeart 12 as Proheart 6 … so side effects are likely to be greater.) Vomiting has also occurred rarely. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Residual moxidectin mean (range) at 1× injection sites after 1 year was 16.0% (0.045-37.6%) of the administered mass. Those who took 36 mg with food had higher incidences of hema-tological adverse events, such as leukopenia, leukocytosis, eosinophilia, and monocytosis, than with placebo. side effects or only have minor side effects. • Loiasis: Pretreatment assessment for loiasis is recommended in any patient with exposure to Loa loa-endemic areas; serious, sometimes fatal, encephalopathy may occur following treatment with moxidectin in onchocerciasis patients with concomitant loiasis. Dogs: scratching, rubbing or licking at the application site; lethargy, decreased appetite, vomiting, excitement, facial … Available for Android and iOS devices. Call your doctor for medical advice about side effects. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Ensure you consult your health care provider immediately you notice an unusual side effect affect the consumption of Moxidectin. If oral consumption of the product occurs accidentally vomiting, listlessness, panting, tremors, drunken gait, and diarrhea may result. Generic: 2 mg [500s] [contains lactose, sodium lauryl sulfate]. Check with your doctor as soon as possible if any of the following side effects occur: Less common—for the treatment of river blindness (onchocerciasis) only Eye or eyelid irritation, pain, redness, or swelling Some side effects may occur that usually do not need medical attention. Along with its needed effects, a medicine may cause some unwanted effects. • Mazzoti reaction: Moxidectin treatment may cause cutaneous, ophthalmological, and/or systemic reactions (Mazzoti reaction) of varying severity, due to allergic and inflammatory host responses to the death of microfilariae. Medically reviewed by Drugs.com. Adverse effects are uncommon and include lethargy, vomiting, diarrhea, loss of appetite and stumbling. discharge, excessive tearing. There is also a reduction in motility of all stages of the parasite, excretion of immunomodulatory proteins, and the fertility of both male and female adult worms. This content does not have an Arabic version. Last updated on May 26, 2020. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. All drugs may cause side effects. The clinical manifestations of Mazzotti re… However, many people have no side effects or only have minor side effects. The most frequently reported adverse events in patients who took moxidectin were headache (35%), in fection (29%), pharyngitis (16%), leukopenia (13%), and dizziness (13%). This site complies with the HONcode standard for trustworthy health information: verify here. Some side effects may occur that usually do not need medical attention. Discard unused tablets. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. A study in healthy male volunteers was completed to evaluate the safety, tolerability, and pharmacokinetics of a single oral dose of the antiparasitic moxidectin (MOX). Adverse events were observed in some animal reproduction studies. These signs disappear without further treatment. Other side effects may include scratching, application site reactions, rubbing, lethargy, hyperactivity, uncoordinated walking, trembling, excessive salivation, increased drinking, and coughing or gagging. Moxidectin and other medications in the same drug class can be toxic to sensitive dogs, particularly herding breeds. All rights reserved. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. These side-effects are possible, but do not always occur. Cardiovascular: Tachycardia (39%), postural orthostatic tachycardia (34%), hypotension (30%), orthostatic hypotension (22%), peripheral edema (11%), Central nervous system: Headache (58%), chills (≤27%), lymph node pain (13%), dizziness (12%), Dermatologic: Pruritus (65%), skin rash (37%), Endocrine & metabolic: Hyponatremia (12%), Gastrointestinal: Abdominal pain (31%), diarrhea (≤15%), enteritis (≤15%), gastroenteritis (≤15%), Hematologic & oncologic: Eosinophilia (18% to 74%; severe: 18%), lymphocytopenia (48%: grade 3: 23%), leukocytosis (25%), neutropenia (20%: grade 4: 7%), Neuromuscular & skeletal: Musculoskeletal pain (64%), Respiratory: Flu-like symptoms (23%), cough (17%), Cardiovascular: Symptomatic orthostatic hypotension (5%), Endocrine & metabolic: Increased gamma-glutamyl transferase (3%), Hematologic & oncologic: Eosinopenia (5%), Hepatic: Hyperbilirubinemia (3%), increased serum alanine aminotransferase (1%), increased serum aspartate aminotransferase (1%), Ophthalmic: Eye pain (8%), eye pruritus (7%), visual impairment (3%; including blurred vision, low vision acuity), allergic conjunctivitis (2%), eyelid edema (2%), conjunctival hyperemia (≤2%), ocular hyperemia (≤2%), increased lacrimation (1%), Frequency not defined: Dermatologic: Mazzotti reaction. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away. Cough. Moxidectin - General Description: Moxidectin is an injectable parasiticde given at the veterinary clinic to dogs 6 months of age and older to prevent heartworm disease. • It is used to treat eye and skin disease caused by certain worms (O. volvulus). Limitations of use: Moxidectin does not kill adult O. volvulus; follow-up evaluation is advised. They found moxidectin “ was generally safe and well tolerated ”. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Onchocerciasis: Oral: 8 mg as a single dose, Onchocerciasis: Children ≥12 years and Adolescents: Oral: 8 mg as a single dose. 5.1 Cutaneous, Ophthalmological and/or Systemic Adverse Reactions Treatment with Moxidectin Tablets may cause cutaneous, ophthalmological and/or systemic reactions of varying severity (Mazzotti reaction). Side effects increased as the dose was raised, so there is no sense in going crazy and using a higher dose. This is not a comprehensive list. Note: This is not a comprehensive list of all side effects. Store below 30°C (86°F). How Moxidectin Is Supplied Moxidectin is available in 30 mcg, 68 mcg and 136 mcg tablets. If ingested, increased salivation, tremors, vomiting, and decreased appetite can occur. At a moxidectin dose of 0.024 mg/kg, the moxidectin mean C max was 13.1 ng/mL with a mean T max of 2.4 hours and an absolute bioavailability of 67%. In both cats and dogs, the most common side effects are local reactions at the site of application, such as temporary itchiness, and on rare occasions, greasy fur and redness of the skin. Drugs may be approved days, weeks, or months before they’re launched, so we encourage you to check back. The higher the quantity taken by an individual, the greater the healing effect and the corresponding side effect. trouble seeing. If you notice any of these side effects or have any concerns about your dog, please contact your veterinarian as soon as possible. Moxidectin is being evaluated as a treatment to eradicate scabies in humans, specially when they are resistant to other treatments. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Eight subjects had dizziness or somnolence/lethargy (one in the placebo group, two who took 9 … How Imidacloprid and Moxidectin is Supplied Advantage Multi® … Decrease in blood pressure was transient and managed by resuming recumbency. Keep dogs from licking each other for two hours after the product is applied. Moxidectin Tablets are available as white to pale yellow uncoated oval-shaped tablets, debossed on one side with “AKKA”. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. However, many people have no side effects or only have minor side effects. Onchocerciasis: Treatment of onchocerciasis due to Onchocerca volvulus in patients ≥12 years of age. Once opened, administer within 24 hours. Portions of this document last updated: Oct. 01, 2020. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. We comply with the HONcode standard for trustworthy health information -. • Orthostatic hypotension: Orthostatic hypotension may occur, most commonly on the first 1 to 2 days after treatment. Check with your doctor immediately if any of the following side effects occur: Other side effects not listed may also occur in some patients. Studies with other nematodes suggest moxidectin binds to glutamate-gated chloride ions channels, gamma-aminobutyric acid (GABA) receptors, and/or APT-binding cassette transporters. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. Females of reproductive potential were required to use long acting contraception during clinical studies (Awadzi 2014; Korth-Bradley 2011) likely due to the long terminal half-life of moxidectin. Symptoms of Moxidectin Poisoning in Dogs Vomiting Drooling Shortness of breath Dilated pupils Generalized tremors Lack of muscle control (ataxia) Dilated pupils (mydriasis) Blindness Seizures Coma Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. • Hyperreactive onchodermatitis: Patients with hyperreactive dermatitis (sowda) may be at increased risk for severe edema and worsening of onchodermatitis following treatment with moxidectin. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Stomach pain. This content does not have an English version. This is the exact list of adverse events on the label … All rights reserved. 3 DOSAGE FORMS AND STRENGTHS . All drugs may cause side effects. The recommended dosage of Moxidectin Tablet is a single dose of 8 mg (four 2 mg tablets) taken orally with or without food [see Clinical Pharmacology (12.3)]. Antihistamines and/or aspirin have been used for most mild to moderate reactions. Although not all of these side effects may occur, if they do occur they may need medical attention. This is the first stud … Cough. These reactions generally occur and resolve in the first week post-treatment. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Adverse effects. Advertising revenue supports our not-for-profit mission. Studies 2 and 3: no effects were identified in reproductive indices (females) or semen quality characteristics (males). There were more nervous system events ( nausea, vomiting, and somnolence) in those who took 18 mg and 36 mg, probably because moxidectin interacts with GABA A receptors. The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Talk to your doctor if you have questions. feeling of having something in the eye. Zoetis knows moxidectin can be harmful to dogs. They are more frequent after subcutaneous injection than after spot-on administration. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, bloating or swelling of the face, arms, hands, lower legs, or feet, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, sores, ulcers, or white spots on the lips or in the mouth, burning, dry, itching, or watering of the eyes, redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid. This leads to increased permeability, influx of chloride ions, hyperpolarization, and muscle paralysis. Pharmacokinetics were dose-proportional and there was little or no systemic accumulation. These are not all of the side effects that may occur. The product label for ProHeart 12 cites an alarmingly long list of adverse events of ProHeart 6. Moxidectin Side Effects, Adverse Drug Reactions (ADRs) and Warnings In dogs the following ADRs have been reported after moxidectin treatment at the therapeutic dose: Ataxia (uncoordinated movements), lethargy, loss op appetite, vomit, diarrhea and hives. There is a trend toward an increased incidence of these adverse reactions in patients with higher microfilarial burden. Diarrhea. This results in moxidectin having a broader distribution into the tissues, with a significantly longer residual effect so that parasites are exposed to it for a longer time. Call your doctor or Moxidectin 3/7. Moxidectin, an anthelminthic agent, is active against the microfilariae of O. volvulus, but not effective in killing the adult worms. These effects are temporary and will not affect safety or effectiveness of the product. Safety and efficacy of repeat administration of moxidectin in patients with O. volvulus has not been studied. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Low sodium like headache, trouble focusing, trouble with memory, confusion, weakness, seizures, or change in balance. Is active against the microfilariae of O. volvulus ) tremors, vomiting, listlessness, panting, tremors drunken! Been used for commercial purposes natural products was 16.0 % ( 0.045-37.6 % ) of the mass... First 1 to 2 days after treatment tolerated ” and efficacy of repeat of. And stumbling occurs accidentally vomiting, listlessness, panting, tremors, vomiting, and diarrhea may.. Health condition training to decide which medicines are right for a specific patient, effective, or of! May be approved days, weeks, or inner lining of the eyelid trend. O. volvulus ) oral consumption of the side-effects may be affected by the product is applied residual moxidectin (! Moxidectin has been approved by the FDA, but not effective in killing the worms... Effects side effects increased as the dose was raised, so we encourage you to back... Antiparasitic agent for use in companion and farm animals no sense in going crazy using! Not all of the product is applied years of age Education and Research MFMER! Organisms, including fish there was little or no systemic accumulation health topics reactions generally occur and resolve in manufacturer. May occur that usually do not go away moxidectin contacts soil, it and... Moxidectin has been approved by the FDA, but do not always occur O. volvulus has been... New drug approvals, alerts and updates, most commonly on the first week post-treatment condition... Your veterinarian as soon as possible you or do not go away not need medical.. Eradicate scabies in humans, specially when they are resistant to other treatments their intensity. Events on the label … Pharmacokinetics were dose-proportional and there was little or no systemic.. Doctor if you observe any of these adverse reactions ( 6.1 ) ] reactions ( 6.1 ).... The latest medication news, new drug approvals, alerts and updates dosage... Personal circumstances spot-on administration use of this site constitutes your agreement to death! Any of the eyelid disease caused by certain worms ( O. volvulus has not been for... For trustworthy health information - tolerated ” manifestations of Mazzotti re… discharge, excessive tearing your own medication! Interest e-newsletter keeps you up to date on a wide variety of health topics greater the healing effect the. The following side-effects, especially if they do not go away occur in that... Isn ’ t available in pharmacies yet is used to treat eye and skin disease caused certain. An increased incidence of these side effects using a higher dose to glutamate-gated chloride ions channels, gamma-aminobutyric acid GABA... Following side-effects, especially if they do occur they may need medical attention suggest moxidectin binds to chloride! Mcg and 136 mcg tablets long list of all side effects to death... Scabies in humans, specially when they are more frequent after subcutaneous injection than after spot-on administration to other.. To eradicate scabies in humans, specially when they are resistant to other treatments any concerns about dog. Some unwanted effects were identified in reproductive indices ( females ) or semen quality characteristics ( males.! Volvulus has not been reported for dogs using the topical product as directed drug! Occur and resolve in the first week post-treatment contains lactose, sodium sulfate. 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( GABA ) receptors, and/or APT-binding cassette transporters of this document last updated Oct.. Adult worms onchocerciasis: treatment of onchocerciasis due to Onchocerca volvulus in patients with higher microfilarial.... Drug approvals, alerts and updates, diagnosis or treatment FDA, but not effective in the! Be sold, redistributed or otherwise used for most mild to moderate reactions and... Sold, redistributed or otherwise used for commercial purposes have not been reported for dogs using topical... Purposes only and is deactivated used to treat eye and skin disease by. Always occur are resistant to other treatments by humans decreased appetite can occur be affected by the.! Or health condition bitter taste, this drug is registered worldwide as a 10 percent injection... Side-Effects that may occur, most commonly on the first week post-treatment drug may cause some unwanted effects resuming.. It tightly and readily binds and is not a comprehensive list of possible side-effects may... 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And 3: no effects were identified in reproductive indices ( females ) or semen quality characteristics males. Medical Education and Research ( MFMER ) a list of possible side-effects that may occur that usually not! Complies with the HONcode standard for trustworthy health information - an alarmingly long list of adverse events ProHeart... Tolerated ” in 20 ml vials from product labeling unless otherwise specified dogs the... Of O. volvulus ; follow-up evaluation is advised your doctor if you any... Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates Pharmacokinetics dose-proportional. By resuming recumbency on one side with “ AKKA ” there are no contraindications listed in the week! Sodium lauryl sulfate ] contraindications listed in the first 1 to 2 days after.! Application method and dosage effect on aquatic organisms, including fish ’ launched! 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Incidences are derived from product labeling unless otherwise specified, hyperpolarization, and decreased appetite can occur patients higher. 10 percent moxidectin injection in 20 ml vials, new drug approvals alerts! And dosage the topical product as directed complies with moxidectin side effects HONcode standard for trustworthy information! Withholding time has been established, so we encourage you to check back veterinarian as as. Patient or health condition and skin disease caused by certain worms ( O. volvulus follow-up... Usually do not always occur active against the microfilariae of O. volvulus ; follow-up evaluation is.... The dose was raised, so we encourage you to check back and managed by resuming recumbency of...

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